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. 2013 May 17;62(6):2048–2058. doi: 10.2337/db12-0931

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Systemic administration of hMSCs or TSG-6 delayed the onset of diabetes in NOD mice. A and B: Diabetes incidence. Negative, HBSS infused (n = 10) at 10 and 11 weeks of age; hMSCs at 14 and 15 weeks, hMSC infused (2 × 10⁶, n = 10) at 14 and 15 weeks of age; hMSCs at 10 and 11 weeks, hMSC infused (2 × 10⁶, n = 10) at 10 and 11 weeks of age; TSG-6 at 10 and 11 weeks, TSG-6 infused (50 µg/mouse, n = 10) at 10 and 11 weeks of age; TSG-6 from 10 to 17 weeks, TSG-6 infused (50 µg/mouse, n = 5) from 10 to 17 weeks of age. *P < 0.05, **P < 0.005 by Kaplan-Meier estimator. C–G: HBSS, HBSS infused (n = 10) at 10 and 11 weeks of age; hMSCs, hMSC infused (2 × 10⁶, n = 10) at 10 and 11 weeks of age; TSG-6, TSG-6 infused (50 µg/mouse, n = 5) from 10 to 17 weeks of age. C: End point–representative H-E and immunofluorescence staining for CD4 and insulin. D and E: Islet number per area and insulitis characterization (n = 3 or 4). F: Representative immunofluorescence staining for Foxp3 and insulin. G: Foxp3⁺ quantification per islet (n = 3 or 4). Values for islet numbers and Foxp3 are means ± SD. *P < 0.05 by two-tailed Student t test.