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. 2013 May 17;62(6):2048–2058. doi: 10.2337/db12-0931

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Administered hMSCs reduced insulitis by secreting TSG-6 in NOD mice. A: Experimental scheme. Insulitis was analyzed in the pancreas after weekly two-time infusions of HBSS or hMSCs at various ages. Islet number per pancreatic section (B) and insulitis characterization (C) from HBSS- (n = 3) or hMSC-infused mice (2 × 10⁶, n = 3) at various ages. Values are means ± SD. *P < 0.05; **P < 0.005. NS, not significant by two-tailed Student t test. Insulitis characterization (D) and insulitis score (E) from 12-week-old mice HBSS (n = 8), Scr siRNA hMSC (2 × 10⁶, n = 6), or TSG-6 siRNA hMSC infused (2 × 10⁶, n = 6) at 10 and 11 weeks of age. Insulitis characterization (F) and insulitis score (G) from 12-week-old mice HBSS (n = 8), hMSC (2 × 10⁶, n = 6), or TSG-6 infused (50 µg, n = 6) at 10 and 11 weeks of age. At least 20 individual islets per mouse were examined for insulitis characterization and score. Insulitis score values are means ± SD. *P < 0.05, **P < 0.005, ***P < 0.0005 by one-way ANOVA. H: Diabetes incidence after diabetogenic splenocytes (10⁷ cells/mouse) pooled from 11-week-old female NOD mice that were intravenously cotransferred with HBSS (n = 8), Scr siRNA–transfected hMSCs (1 × 10⁶, n = 7), or TSG siRNA–transfected hMSCs (1 × 10⁶, n = 7). *P < 0.05 by Kaplan-Meier estimator.