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. 2013 May 22;8(5):e63759. doi: 10.1371/journal.pone.0063759

Figure 5. ATP degradation, P2X7 inhibition and Caspase-1 and inflammasome inhibition attenuated the protective effect of ATP against bacterial infection.

Figure 5

(A) YVAD (5 mg/kg), Apyrase (50 U/kg) or BBG (60 mg/kg) pre-injection prior to ATP reduced the survival rate of the mice infected with E. coli 25922 (n = 10, P<0.05 by log-rank test). (B) YVAD (5 mg/kg), Apyrase (50 U/kg) or BBG (60 mg/kg) pre-injection before ATP reduced the survival rate of mice infected with S. aureus 25923 (n = 10, P<0.05 by log-rank test).