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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Jun;72(6):462–471. doi: 10.1097/NEN.0b013e3182933788

Figure 3.

Figure 3

Association between reactive glia and dense-core plaques. (a, b) Note the intimate interaction between dense-core plaques (stained green with Thioflavin-S) and glial fibrillary acidic protein (GFAP)-positive astrocytes (a) and Iba1-positive microglia (b), in red. (c, d) The densities of GFAP-positive astrocytes or Iba1-positive microglial cells with respect to the nearest dense-core plaque were determined using stereology-based methods in a glia-centered fashion. GFAP-positive astrocytes (c) and Iba1-positive microglia (d) are more abundant in the vicinity (<50 μm) of dense-core plaques than far away from them (>50 μm) (*** p = 0.0001).