Figure 7. Dual target molecular PET/MRI after therapeutic RNA silencing of CCR2.
A, Short axis PET/MRI images after respective siRNA treatment. Bar graph of standard uptake value (SUV) shows no difference in 18F-FXIII PET signal between treatment groups (n=5 per group). B, Short axis MRI showing MPO-Gd signal enhancement in siCON and reduced enhancement in siCCR2 treated mice. Arrows indicate infarct area. The bar graph shows contrast-to-noise ratio (CNR). Data are mean±SEM, *p<0.05.