Table 1.
Subunits of chromatin-remodeling complexes that influence embryonic blood vessel development
| Subfamily | Subunit | Mutation | Vascular phenotype | References |
|---|---|---|---|---|
| SWI/SNF | BRG1 | Endothelial cell knockout (Tie2-Cre +) | Yolk sac angiogenesis defects due to downregulated vascular Wnt signaling; hypotrabeculation of the heart due to overexpression of Adamts1; lethality between E10.5-11 | [44, 53, 64] |
| BAF180 | Global knockout | Defective coronary vascular development due to failed EMT and migration of epicardial cells | [66] | |
| BAF155 | Global knockout with partial transgenic rescue | Yolk sac angiogenesis defects | [65] | |
| CHD | CHD4 | Endothelial cell knockout (Tie2-Cre +) | Rescues Brg1 fl/fl :Tie2-Cre + yolk sac angiogenesis defects | [74] |
| ISWI | No blood vessel phenotypes currently described | |||
| INO80 | No blood vessel phenotypes currently described | |||