Table 3.

(A) Release kinetics (% release per day) of IGF-1 (n=5) and (B) release kinetics (% release per day) of active IGF-1 in Group 1 in collagenase-PBS (n=4) from OPF composite hydrogels in phase 1 (~ 24 hrs), phase 2 (1–4 days), phase 3 (4–8 days), and phase 4 (18–28 days).

(A)
Experimental Groups	Phase 1 (%/day) (~ 24 hrs)		Phase 2 (%/day) (Days 1 – 4)		Phase 3 (%/day) (Days 4–18)		Phase 4 (%/day) (Days 18 – 28)
	Collagenase- PBS	PBS	Collagenase- PBS	PBS	Collagenase- PBS	PBS	Collagenase -PBS	PBS
Group 1	31.1 ± 2.8	27.3 ± 2.8	4.3 ± 0.4	2.4 ± 0.3	2.1 ± 0.2	2.5 ± 0.5	0.9 ± 0.1	1.1 ± 0.6
Group 2	31.7 ± 1.8	31.7 ± 1.8*	4.8 ± 0.3	2.5 ± 0.2	1.9 ± 0.3	1.8 ± 0.4*	0.9 ± 0.1	1.8 ± 0.5
Group 3	28.1 ± 2.3	27.6 ± 2.3	4.2 ± 0.6	2.7 ± 0.2	2.1 ± 0.2	2.8 ± 0.2	1.0 ± 0.1	1.0 ± 0.2

(B)
	Phase 1 (%/day) (~ 24 hrs)	Phase 2 (%/day) (Days 1 – 4)	Phase 3 (%/day) (Days 4 – 18)	Phase 4 (%/day) (Days 18 – 28)
Active IGF-1 Release (Group 1, collagenase-PBS)	26.2 ± 13.4	3.5 ± 2.3	1.7 ± 0.6	0.6 ± 0.1

^(*)indicates a significant difference between groups in the same phase (p<0.05).