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. 2013 May 22;8(5):e63745. doi: 10.1371/journal.pone.0063745

Figure 8. Expression of spliced histone transcripts are increased during committed osteoblast differentiation.

Figure 8

(A) hFOB 1.19 cells were differentiated into osteoblasts for 7 days. Alkaline phosphatase (ALPL) expression in undifferentiated (undiff.) and differentiated (OB) cells was analyzed by qRT-PCR. Values were normalized to HNRNPK expression. Mean±SD, n = 3. (B, C) Samples shown in (A) were examined for (B) spliced HIST1H2BD and (C) HIST1H2AC expression. Values were normalized to total HISTH2BD and HISTH2AC respectively. Mean±SD, n = 3. P-values were calculated and statistical significance is represented as follows (*P≤0.05; **P≤0.01).