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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Mol Psychiatry. 2013 Feb 19;19(3):351–357. doi: 10.1038/mp.2013.19

Figure 2. Manhattan plot of observed −log10 p-values from the GWAS of cortical Aβ load.

Figure 2

More than six million SNPs were tested for association to global cortical Aβ burden under an additive genetic model and applying age, gender, and diagnosis as covariates. Genome-wide significant associations (exceeding the threshold represented by the red line) were identified on chromosome 19 within APOE and its neighboring genes and on chromosome 3 at the BCHE locus. Suggestive associations (exceeding the threshold represented by the blue line) were identified on five additional chromosomes. Annotations are provided for genome-wide significant associations and for the top three suggestive associations.