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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Mol Psychiatry. 2013 Feb 19;19(3):351–357. doi: 10.1038/mp.2013.19

Figure 4. APOE ε4 and rs509208 (BCHE) appear to exhibit independent, additive effects on cortical Aβ levels.

Figure 4

Mean cortical Aβ levels (adjusted for age, gender, and diagnosis) ± standard errors are displayed based on A) the number of APOE ε4 allele copies and B) rs509208 genotype. Presence of at least one copy of the ε4 allele was significantly associated with increased Aβ burden (Cohen’s d = 0.71), as was presence of at least one copy of the minor allele (G) of rs509208 (Cohen’s d = 0.52). These loci appeared to exert additive effects on Aβ levels (panel C): subjects having both risk factors exhibited significantly greater Aβ burden than subjects having either factor in isolation, and no significant epistasis modeled as an interaction was identified.