Table II.
General characteristics of the healthy control group and the CF groups with a normal nutritional status and with nutritional failure
| Healthy controls (n=17) | CF no nutritional failure (n=9) | CF nutritional failure (n=7) | |
|---|---|---|---|
| Sex (M/F) | 8/9 | 5/4 | 5/2 |
| Age (yrs) | 22.2 ± 5.6 | 15.5 ± 5.9*** | 15.2 ± 6.2*** |
| Genotypes (#) | DF508/DF508 (11), G551D/DF508 (2), DF508/G1244E (1), DF508/1717-1G TO, A (1), DF508/3272-26A>G (1). | ||
| Tanner stage (n: 1, 2–4, 5) | 1/5/3 | 0/6/1 | |
| Weight (kg) | 69.4 ± 17.4 | 54.6 ± 20.6 | 42.2 ± 17.2 |
| BMI (percentile) | 54.8 ± 20.7 | 7.9 ± 3.2## | |
| (kg/m2) | 22.0 ± 5.5 | ||
| Height (m) | 1.77 ± 0.44 | 1.61 ± 0.61 | 1.62 ± 0.66 |
| (percentile) | 37.0 ± 14.0 | 36.3 ± 14.8 | |
| FFMI (% norm) | 99.3 ± 24.8 | 99.0 ± 40.4 | 81.8 ± 33.4 |
| FMI (% norm) | 106.8 ± 26.7 | 104.7 ± 39.6 | 79.0 ± 32.2 |
| FEV1 (% pred) | 88.9 ± 33.6 | 74.6 ± 30.4 | |
| FVC (% pred) | 104.0 ± 39.3 | 88.7 ± 36.2 | |
| Weight change 3 mo. before admission (kg) | 0.7 ± 0.2 | −1.7 ± 0.7# | |
| Weight change admission until study day (kg) | 1.9 ± 0.7 | 1.9 ± 0.8 | |
| Exacerbations past year (nr) | 0.8 ± 0.3 | 3.6 ± 1.5# | |
| Hospitalizations past year (nr) | 0.4 ± 0.1 | 2.0 ± 0.8# | |
Values are means ± SEM. CF: cystic fibrosis; BMI: body mass index; FFMI: fat-free mass index; FMI: fat mass index; FEV1: forced expiratory volume in one second; FVC: forced vital capacity. Significance of difference as compared with healthy controls:
**
P < 0.01,
***
P < 0.001, and to CF with no nutritional failure:
#
P < 0.05,
##
P < 0.01,
###
P < 0.001.