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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Mutat Res. 2013 Jan 17;0:78–88. doi: 10.1016/j.mrfmmm.2013.01.001

Figure 1. A schematic model for the FA/BRCA pathway.

Figure 1

FANCM (blue) with the help of MHF1/2 (dark grey) and FAAP24 (light grey) recruit a large multi-subunit ubiquitin E3 ligase, termed the FA core complex (blue), to sites of DNA damage. The core complex then mono-ubiquitinates FANCD2 and FANCI, mono-ubiquitinated FANCD2-FANCI (green) are recruited to sites of damage by FANCJ (yellow) and BRCA1 (yellow). These FA proteins colocalize with downstream FA proteins (RAD51, FANCN, FANCD1/BRCA2) (yellow), and facilitate DNA interstrand cross-link repair.