Table 1. Somatic mutations of HNSCC patient tumors in a select subset of FA- and DNA-repair associated genes.

[136] Each letter in parentheses represent each individual patient. Mutations were identified by exome sequencing of tumors isolated from sporadic head and neck squamous cell carcinoma patients [136].

FA-Associated Genes	Description	Mutation Types	Amino Acid Change
ATM	ataxia telangiectasia mutated isoform 1	Missense	p.I2899M
		Missense	p.S974F (a)
ATR	ataxia telangiectasia and Rad3 related protein	Nonsense	p.W1784* (b)
		Missense	p.S1701F (b)
		Missense	p.E1840Q (c)
		Missense	p.A248S (c)
BRCA1	breast cancer 1, early onset isoform 2	Missense	p.E554G
		Missense	p.R1670K (d)
		Missense	p.V627I (d)
BRCA2	breast cancer 2, early onset	Nonsense	p.Y2884*
		Missense	p.A1411T
		Missense	p.E97V (e)
		Splice_Site	(f)
		Missense	p.K1530E
BLM	Bloom syndrome protein	Missense	p.D294N (g)
ERCC5	XPG-complementing protein	Missense	p.Q1002R (a)
ERCC6	excision repair cross-complementing rodent	Missense	p.R928T (h)
ERCC8	excision repair cross-complementing rodent	Missense	p.D371H (f)
FANCC	Fanconi anemia, complementation group C	Missense	p.T319R (b)
FANCI	Fanconi anemia, complementation group I isoform	Missense	p.C558F
FANCM	Fanconi anemia, complementation group M	Missense	p.I633M (i)
		Missense	p.V1951E (a)
		Missense	p.H2016D (j)
		Missense	p.S981L (k)
		Nonsense	p.Q1701*
RAD50	RAD50 homolog isoform 1	Missense	p.E1106Q (e)
RAD51AP1	RAD51 associated protein 1 isoform a	Missense	p.S263C
RAD51AP2	RAD51 associated protein 2	Nonsense	p.Q5* (d)
		Missense	p.S355R
RAD51C	RAD51 homolog C isoform 1	Missense	p.M118I (i)
		Missense	p.Q340K (m)
RAD51L1	RAD51-like 1 isoform 2	Missense	p.E167K (g)
RAD52	RAD52 homolog	Missense	p.G59R (n)
RAD54B	RAD54 homolog B	Missense	p.L428V (i)
RAD9B	RAD9 homolog B	Frame_Shift	p.V412fs (h)
RADIL	Rap GTPase interactor	Missense	p.P249R (o)
REV1	REV1-like isoform 1	Missense	p.R874W (p)
RMI1	RMI1, RecQ mediated genome instability 1,	Missense	p.E617D (m)
UBE2E2	ubiquitin-conjugating enzyme E2E 2	Missense	p.S46F (h)
		Missense	p.D22H (g)
UBE2I	ubiquitin-conjugating enzyme E2I	Missense	p.W103C (i)
UBE2J2	ubiquitin conjugating enzyme E2, J2 isoform 1	Missense	p.I113F (j)
UBE2NL	ubiquitin-conjugating enzyme E2N-like	Nonsense	p.K95* (r)
UBE2Q1	ubiquitin-conjugating enzyme E2Q	Missense	p.M206I (k)
UBE3A	ubiquitin protein ligase E3A isoform 2	Missense	p.K489E (a)
		Missense	p.S166R
UBE4A	ubiquitination factor E4A	Missense	p.E616K
		Missense	p.E822D (i)
		Missense	p.E827K (i)
		Missense	p.L605V
UBE4B	ubiquitination factor E4B isoform 1	Nonsense	p.E114* (o)
USP12	ubiquitin thiolesterase 12	Missense	p.A341E (j)
USP13	ubiquitin thiolesterase 13	Missense	p.A561T (s)
		Missense	p.P729L (d)
USP19	ubiquitin thioesterase 19	Nonsense	p.Y941*
USP40	ubiquitin thioesterase 40	Nonsense	p.G641* (o)
USP44	ubiquitin thiolesterase 44	Missense	p.E226Q (n)
		Missense	p.E167Q (n)
		Missense	p.S64T (n)
USP7	ubiquitin specific peptidase 7	Missense	p.M1070V
USP8	ubiquitin specific peptidase 8	Missense	p.D359H (f)
		Missense	p.V736I
USP29	ubiquitin specific peptidase 29	Missense	p.T584N (r)
USP36	ubiquitin specific peptidase 36	Missense	p.I191M (k)
USP45	ubiquitin specific peptidase 45	Missense	p.K180R (t)
USP17L2	deubiquitinating enzyme 3	Missense	p.Q430E (k)
USP4	ubiquitin specific protease 4 isoform a	Missense	p.R179P (f)
		Missense	p.R40Q (f)
USP24	ubiquitin specific protease 24	Missense	p.Y343H (c)
USP26	ubiquitin-specific protease 26	Missense	p.K734N
		Missense	p.V906L (p)
USP28	ubiquitin specific protease 28	Missense	p.E371Q (k)
USP35	ubiquitin specific protease 35	Missense	p.E55K (k)
USP43	ubiquitin specific protease 43	Missense	p.S455F
		Missense	p.R206Q (k)
		Missense	p.E834V (t)
USP47	ubiquitin specific protease 47	Missense	p.I1263V
USP51	ubiquitin specific protease 51	Missense	p.F624L (j)
USP9X	ubiquitin specific protease 9, X-linked isoform	Missense	p.P1105L (s)
		Missense	p.W512L (p)
USP9Y	ubiquitin specific protease 9, Y-linked	Missense	p.I226F
WDR48	WD repeat domain 48	Splice_Site	(i)