Table 5.
Correlation between immunohistochemical proportion score and gene expression
| Target | IHC score (PS) | Correlation coefficient | P value | |||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |||
| CK5/6 | 0.03±0.02 | No sample | 0.04±0.00 | 3.24±5.43 | 0.43 | 0.010* |
| CK7 | 0.01±0.01 | 0.10±0.27 | 0.10±0.22 | 11.16±31.6 | 0.36 | 0.0015* |
| CK14 | 0.03±0.08 | 0.70±1.55 | 13.4±20.7 | 30.13±45.9 | 0.48 | <0.001** |
| CK18 | 0.05±0.06 | 0.11±0.00 | 0.24±0.13 | 5.52±15.7 | 0.52 | <0.001** |
| TTF-1 | 1.58±1.32 | No sample | 45.3±76.8 | 339.5±470.8 | 0.26 | 0.07 |
*P<0.05, **P<0.001.
Proportion score determined by the ratio of positive staining cells: 0, none; 1, <10%; 2, 10–50%; 3, 51–80%; 4, >80%.