Figure 3.

Regression lines of change from baseline for insulin sensitivity (1/I_F µU/mL) versus BMI change, from baseline to 6 months (A) and baseline to 24 months (B); and regression lines of change from baseline for HbA_1c (%) vs. BMI change, from baseline to 6 months (C) and baseline to 24 months (D), by treatment. Treatment groups are denoted by M, M+R, and M+L. The horizontal axis scales represent the 5th–95th percentiles of the distribution of BMI change from baseline (−3 to 3 at 6 months and −4 to +7 at 24 months). Note that the 5th–95th percentile range of BMI change from baseline is greater for the 24-month period than for the 6-month one. Slopes indicate change in insulin sensitivity or HbA_1c per unit increase in BMI change and were evaluated from models including the baseline value of either insulin sensitivity or HbA_1c as a covariate.