Table 3.

Key pathological features of different lesions types in NMO

Les. Type	T	Gr	C9n	AG	Demy	OG loss	Ax loss
1	++	+++	+++	Necrosis	+	Apo	+
				AQP4 variable
				AQP1 variable
				GFAP variable
2	+/++	±	±	AQP4 loss	Complete	+++	+++
				AQP1 loss
				GFAP loss
3	–	–	–	React. gliosis	+++	++	+++
4	±	–	–	AQP4 loss	–	–	–
				Clasmatodendrosis +
5	++	–	–	Clasmatodendrosis +++	–	–	–
				AQP4 loss
				AQP1 loss
				GFAP loss
6	++	–	–	Clasmatodendrosis +/++	Complete	+++	++
				AQP4 loss variable
				AQP1 loss variable
				GFAP loss ±

Les.Type lesion type, T T cells, Gr granulocytes, C9n complement C9neo antigen, AG astroglia pathology, Demy demyelination, OG loss loss of oligodendrocytes, Ax. Loss axonal loss

±, minor or absent; +, minor; ++, moderate; +++, severe