Table 2.

Pharmacophore properties of compound I and II

Pharmacophore feature/property	Compound I	Compound II
Positive ionization (red)	Nitrogen atom	Nitrogen atom
Hydrogen bond acceptor (HBA, green)	Carbonyl group of amide bond	Carbonyl group of amide bond
Aromatic ring (orange)	Benzene ring substituted with methoxy group	Benzene ring substituted with two methoxy groups
Hydrophobic, aromatic (pale blue)	Furane ring	Furane ring
Hydrophobic, aliphatic (ultramarine)	One methyl group in methoxy moiety attached to the benzene ring	Two methyl groups in methoxy moieties attached to the benzene ring