Table 3.
Pharmacophore geometry parameters
| Pharmacophore geometry parameters | Compound I | Compound II |
|---|---|---|
| Distance between piperidine nitrogen atom and center of the benzene ring | 7.85 Å | 7.76 Å |
| Dihedral angle between benzene ring plane and furane ring plane | 72.50° | 63.29° |
| Dihedral angle between piperidine ring (C1/C2/C4/C5) plane and benzene ring plane | 65.79° | 50.97° |
| Dihedral angle between piperidine ring (C1/C2/C4/C5) plane and furane ring plane | 69.42° | 87.56° |
| Dihedral angle between carbonyl group plane and piperidine ring plane | 73.50° | 86.72° |