Table 1.
Human telomerase regulation
| Telomerase inducers | |
| Leptin [45] | HBZ (HTLV1 bZIP factor) [92] |
| EGFR [46] | LANA (latency-associated nuclear antigen) [93] |
| Survivin* [94] | Her2/Neu/Ras/Raf [44] |
| Sp1 [95] | ΔNp73 [96] |
| Mad1/c-Myc [97, 98] | Ets2 [99] |
| HBX protein (X protein of HBV) [100] | STAT3 [101] |
| HPV16 E6 [102] | Estrogen receptors (ERs) ERα and ERβ [47] |
| ERK/ER81 [28, 44, 103, 104] | 17β - estradiol (E2) [47, 50] |
| Telomerase repressors | |
| Dexamethasone (Dex) [60] | Egr-1(early growth response 1) transcription factor [105] |
| Gefitinib* [64] | TGFβ [106] |
| Genistein (phytoestrogen)* [61] | PTEN [107] |
| Upstream stimulatory factor (USF) 1 and 2 [108] | IP6* [109] |
| WT1 (Wilm’s tumor 1 suppressor gene product) [110] | Imatinib mesylate* [111] |
| MZF-2 [112, 113] | Indole-3-carbinol (I3C)[51] |
| p53-Sp1 complex [114] | BRCA1 gene [52, 53] |
| p53/p21/Rb/E2F [95] | Nmi (N-myc and c-myc interacting protein)[54] |
| p73 [115] | Rad50 [55] |
| NFX1-91 [116] | Raloxifene [62] |
| Interferon-γ [117] | Melatonin [63] |
| CTCF [118, 119] | Butein (3,4,2′,4′-tetrahydroxychalcone) [64] |
| PPARγ (peroxisome proliferator-activated receptor γ) [120] | Pectenotoxin-2 (PTX2) [65] |
| PPAR α (peroxisome proliferator-activated receptor α) [121] | Imetelsat sodium (GRN163L) [68] |
| Menin [106] | ATRA (all-trans retinoic acid) [71] |
| TR antisense oligonucleotides [77] | Sulforaphane (SFN) [72] |
| BIBR1532 [80] | |