Figure 1.

Ion channels and regulation of membrane excitability. Neurons within the arcuate nucleus typically have a RMP of ~55 mV (See text). Cations rush in through open channels when RMP is more negative to the equilibrium potentials (pink-colored channels). By contrast, cations rush out or anions rush in through open channels when RMP is more positive to the equilibrium potentials (blue-colored channels). Equilibrium potentials were calculated using Nernst equation assuming experimental conditions in Sohn et al. (2011).