Fig. 5.

Effects of intra-striatal infusion of the PPARδ agonist GW0742 on MPTP neurotoxicity. (A) Representative micrographs of TH and Nissl-stained sections following infusion with GW0742 or vehicle (25% DMF in PBS) (Scale bar = 200 μm). Infusion of GW0742 reduced MPTP-induced loss of TH-positive (B) and Nissl-positive (C) neurons compared to infusion of vehicle. Data are mean ± SEM, n = 3–5 mice per group. ^∗p < 0.05 (ANOVA with Student–Newman–Keuls post hoc test; Nissl – Kruskal–Wallis test with Mann–Whitney U-post hoc test) (TH – tyrosine hydroxylase; SNpc – substantia nigra pars compacta).