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Activity and receptor selectivity of GW0742 and GSK0660. The activity of GW0742 is expressed as the EC50 (μM) for this compound in a transactivation assay (Sznaidman et al., 2003), whilst the activity of GSK0660 is expressed as the IC50 (μM) in a GAL4 LBD chimera assay (Shearer et al., 2008)
| PPARα | PPARγ | PPARδ | Selectivity for PPARδ | |
|---|---|---|---|---|
| GW0742 (EC50 μM) | 1.1 | 2 | 0.001 | >1000-fold |
| GSK0660 (IC50 μM) | >10 | >10 | 0.155 | >1000-fold |
