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. 2013 Jun 14;240:191–203. doi: 10.1016/j.neuroscience.2013.02.058

Table 2.

Effects of genetic manipulation of PPARδ levels on striatal dopamine and DOPAC levels. No difference is seen between wild-type mice and their heterozygous littermates (null mice were not viable) in their sensitivity to MPTP toxicity as measured by reduction in dopamine and DOPAC levels. Data are mean ± SEM, n = 7 mice per group. ∗∗∗p < 0.001 compared to appropriate saline-treated group (Kruskal–Wallis test with Mann–Whitney U-post hoc tests; WT – wild-type, Het – heterozygous)

Saline
MPTP
WT Het WT Het
Dopamine (ng/mg wet tissue) 15.98 ± 1.87 19.06 ± 2.05 2.67 ± 0.44∗∗∗ 1.73 ± 0.34∗∗∗
DOPAC (ng/mg wet tissue) 2.07 ± 0.32 1.85 ± 0.60 0.50 ± 0.06∗∗∗ 1.12 ± 0.42