Figure 1.

Diagram summarizing RBP-mediated regulation of different cue-stimulated responses in axonal growth cones. In the growth cone, RBPs mediate translation of specific mRNAs after cue stimulation. Netrin-1 induces ZBP1 localization and translation of β-actin close to the source of Netrin-1, and this is crucial for growth cone turning (Leung et al., 2006; Lin and Holt, 2007). BDNF induces Src-mediated ZBP1 phosphorylation, β-actin translation and growth cone turning toward the BDNF source (Yao et al., 2006; Sasaki et al., 2010). Growth cone collapses and Map1B mRNA translation in response to Sema3a is attenuated in axons depleted of FMRP, suggesting a role for FMRP in Sema3A-mediated axon guidance (Li et al., 2009). NT3 induces CamKII mediated phosphorylation of CPEB1, which activates polyadenylation and translation of β-catenin mRNA crucial for axon elongation and branching (Kundel et al., 2009).