Table 2.
Relationship between maternal pre-pregnancy fat mass (kg) and wheeze and atopy phenotypes in the offspring at age 6 years
| Unadjusted analysis | Model 1 | Model 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Outcome | RR | (95% CI) | P-value | n | RR | (95% CI) | P-value | n | RR | (95% CI) | P-value | n |
| Ever wheeze | 1.09 | (1.03, 1.16) | 0.003 | 921 | 1.08 | (1.02, 1.15) | 0.007 | 895 | 1.09 | (1.03, 1.16) | 0.002 | 895 |
| Ever asthma | 1.10 | (0.93, 1.31) | 0.27 | 927 | 1.05 | (0.89, 1.24) | 0.57 | 890 | 1.10 | (0.93, 1.30) | 0.28 | 890 |
| Current wheeze | 1.04 | (0.86, 1.25) | 0.68 | 927 | 1.06 | (0.87, 1.29) | 0.54 | 808 | 1.09 | (0.90, 1.32) | 0.39 | 808 |
| Current asthma | 1.14 | (0.91, 1.43) | 0.24 | 927 | 1.10 | (0.89, 1.37) | 0.39 | 918 | 1.14 | (0.92, 1.41) | 0.22 | 918 |
| Transient wheeze | 1.13 | (1.05, 1.23) | 0.002 | 764 | 1.11 | (1.02, 1.20) | 0.01 | 743 | 1.12 | (1.03, 1.21) | 0.006 | 743 |
| Persistent wheeze | 1.12 | (0.96, 1.30) | 0.14 | 526 | 1.08 | (0.94, 1.24) | 0.26 | 519 | 1.11 | (0.98, 1.27) | 0.11 | 519 |
| Atopy | 1.07 | (0.91, 1.25) | 0.43 | 681 | 1.14 | (0.97, 1.35) | 0.12 | 590 | 1.14 | (0.97, 1.35) | 0.12 | 590 |
| Model 3 | Model 4 | |||||||||||
| RR | (95% CI) | P-value | n | RR | (95% CI) | P-value | n | |||||
| Ever wheeze | 1.1 | (1.03, 1.17) | 0.004 | 817 | 1.09 | (1.03, 1.15) | 0.004 | 893 | ||||
| Ever asthma | 1.14 | (0.96, 1.35) | 0.13 | 823 | 1.06 | (0.89, 1.28) | 0.52 | 888 | ||||
| Current wheeze | 1.03 | (0.84, 1.28) | 0.76 | 741 | 1.09 | (0.89, 1.33) | 0.40 | 806 | ||||
| Current asthma | 1.17 | (0.94, 1.45) | 0.16 | 835 | 1.14 | (0.91, 1.42) | 0.27 | 915 | ||||
| Transient wheeze | 1.11 | (1.02, 1.21) | 0.01 | 686 | 1.11 | (1.02, 1.20) | 0.01 | 741 | ||||
| Persistent wheeze | 1.12 | (0.97, 1.30) | 0.13 | 478 | 1.10 | (0.96, 1.27) | 0.17 | 519 | ||||
| Atopy | 1.21 | (1.02, 1.44) | 0.03 | 546 | 1.15 | (0.97, 1.36) | 0.12 | 590 | ||||
Relative risk represents change in outcome per 10 kg of maternal pre-pregnancy fat mass.
Model 1 Adjusted for potential confounders significantly associated with the outcome, excluding child’s birthweight, gestation.
Ever wheeze-maternal education, asthma and rhinitis, child’s gender and age last breastfed; Ever asthma- maternal education, asthma and smoking in pregnancy, and child’s gender; Current wheeze-maternal education, asthma and atopy; Current asthma-maternal education and asthma; Transient wheeze-maternal height, parity, asthma and rhinitis, child’s gender and age last breastfed; Persistent wheeze-maternal education, asthma and rhinitis and child’s gender; Atopy-maternal social class, asthma and atopy, and child’s gender.
Model 2 adjusted for potential confounders significantly associated with the outcome, including child’s birthweight, gestation.
Ever wheeze-maternal education, asthma and rhinitis, child’s gender, age last breastfed and gestation; Ever asthma- maternal education, asthma, smoking in pregnancy and parity, child’s gender and gestation; Current wheeze-maternal education, asthma and atopy, child’s gender and gestation; Current asthma-maternal education and asthma, and child’s gestation; Transient wheeze-maternal height, parity, asthma and rhinitis, child’s gender, age last breastfed and gestation; Persistent wheeze-maternal education, asthma and rhinitis, child’s gender and gestation; Atopy-maternal social class, asthma and atopy, and child’s gender.
Model 3 adjusted for increase in adiposity between birth and 6 months and potential confounders significantly associated with the outcome (listed in Model 2) including child’s birthweight and gestation.
Model 4 adjusted for child’s BMI at age 6 years and potential confounders significantly associated with the outcome including child’s birthweight and gestation.