Table 3.

Relationship between maternal pre-pregnancy BMI and wheeze and atopy phenotypes in the offspring at age 6 years

	Unadjusted analysis				Model 1				Model 2
Outcome	RR	(95% CI)	P-value	n	RR	(95% CI)	P-value	n	RR	(95% CI)	P-value	n
Ever wheeze	1.08	(1.02, 1.14)	0.006	924	1.07	(1.01, 1.12)	0.01	897	1.08	(1.02, 1.13)	0.004	897
Ever asthma	1.07	(0.92, 1.24)	0.4	930	1.02	(0.87, 1.18)	0.84	892	1.06	(0.91, 1.24)	0.44	892
Current wheeze	0.99	(0.85, 1.16)	0.94	930	0.99	(0.84, 1.17)	0.94	809	1.02	(0.87, 1.20)	0.79	809
Current asthma	1.10	(0.91, 1.33)	0.31	930	1.06	(0.88, 1.27)	0.53	920	1.10	(0.92, 1.32)	0.30	920
Transient wheeze	1.11	(1.04, 1.18)	0.003	767	1.10	(1.03, 1.17)	0.006	746	1.11	(1.04, 1.18)	0.002	746
Persistent wheeze	1.08	(0.95, 1.24)	0.22	527	1.05	(0.93, 1.20)	0.42	519	1.09	(0.97, 1.24)	0.16	519
Atopy	1.08	(0.94, 1.24)	0.31	681	1.13	(0.98, 1.31)	0.10	589	1.13	(0.98, 1.31)	0.1	589
					Model 3				Model 4
					RR	(95% CI)	P-value	n	RR	(95% CI)	P-value	n
Ever wheeze					1.08	(1.02, 1.14)	0.009	819	1.07	(1.02, 1.13)	0.01	895
Ever asthma					1.08	(0.92, 1.26)	0.34	825	1.02	(0.86, 1.20)	0.85	890
Current wheeze					0.97	(0.82, 1.16)	0.77	742	1.02	(0.86, 1.22)	0.79	807
Current asthma					1.10	(0.91, 1.33)	0.31	837	1.10	(0.90, 1.34)	0.35	917
Transient wheeze					1.10	(1.03, 1.18)	0.006	689	1.10	(1.03, 1.18)	0.007	744
Persistent wheeze					1.09	(0.95, 1.25)	0.23	478	1.08	(0.95, 1.23)	0.25	519
Atopy					1.17	(1.00, 1.36)	0.05	545	1.14	(0.98, 1.32)	0.09	589

Relative risk represents change in outcome per 5 kg m⁻² of maternal pre-pregnancy BMI.

Models 1-4 adjusted for confounders as described in Table 2.