Table 1.
Demographic and cognitive between-group comparisons (significant between-group differences defined as p<0.05 appear in bold)
| Variable | MCIc, n=46 | MCInc, n=64 | p-value |
|---|---|---|---|
| Age, yr | 73.5 (6.9) | 71.9 (6.3) | 0.2 |
| Education, yr | 15.0 (3.5) | 15.4 (2.8) | 0.5 |
| Sex, M:F | 29:26 | 42:24 | 0.2 |
| ApoE4+ subjects | 42 (87.5%) | 32 (50.8%) | <0.001 |
| Treatment arm | Donepezil 25% Vitamin E 32% Placebo 43% |
Donepezil 26% Vitamin E 31% Placebo 43% |
p=0.98 |
| MMSE at baseline | 26.8 (1.6) | 28.2 (1.6) | <0.0001 |
| ADAScog baseline | 13.1 (3.5) | 9.1 (3.3) | <0.0001 |
| ADL baseline | 45.3 (4.1) | 47.8 (3.0) | 0.001 |
| ADAS verb mem at baseline | 4.3 | 2.43 | <0.0001 |
| ADAS construction at baseline | 0.5 | 0.55 | 0.6 |
| Maze errors at baseline | 0.06 | 0.21 | 0.041 |
| MMSE 3-year change | −5.2 (5.4) | 0.11 (2.1) | <0.0001 |
| ADAScog 3-year change | 8.2 (8.6) | −0.03 (4.0) | <0.0001 |
| ADL 3-year change | 13.8 (11.0) | 0.32 (3.7) | <0.0001 |
| ADAS verb mem, 3-year change | 1.5 (1.9) | 0.19 (2.2) | 0.002 |
| ADAS construction, 3-year change | −0.56 (0.8) | 0.02 (0.6) | <0.0001 |
| Maze errors, 3-year change | −0.19 (0.8) | 0.03 (0.3) | 0.1 |
| Baseline hippocampal volume (mm3) | Left 3351 (484) Right 3200 (508) |
Left 3524 (495) Right 3460 (530) |
Left 0.056 Right 0.007 |
| Baseline frontal horn volume (mm3) | Left 12610 (1811) Right 14183 (3518) |
Left 12441 (1680) Right 12510 (3129) |
Left 0.6 Right 0.007 |
| Baseline temporal horn volume (mm3) | Left 760 (159) Right 1133 (222) |
Left 726 (132) Right 1141 (173) |
Left 0.2 Right 0.8 |
| Baseline body/occipital horn volume (mm3) | Left 6748 (2054) Right 7130 (1671) |
Left 6172 (1783) Right 7043 (1842) |
Left 0.1 Right 0.8 |