Table 2.

Permutation-corrected p-values of the associations between change in ADAScog, MMSE and ADL and ventricular enlargement with and without controlling for baseline frontal horn volume and hippocampal atrophy (significant p-values defined as p<0.05 appear in bold)

Measure	Ventricular subregion	Uncorrected		Controlling for baseline frontal horn volume		Controlling for whole ventricular volume		Controlling for hippocampal atrophy
		Left	Right	Left	Right	Left	Right	Left	Right
ADAScog	Temporal horn	0.038	0.055	0.07	0.14	0.089	0.11	0.04	0.037
	Body/occipital horn	0.028	0.0022	0.027	0.0037	0.02	0.0036	0.031	0.035
	Frontal horn	0.32	0.56	0.25	0.54	0.19	0.53	0.34	0.46
MMSE	Temporal horn	0.2	0.026	0.31	0.039	0.41	0.039	0.18	0.019
	Body/occipital horn	0.024	0.015	0.02	0.024	0.014	0.024	0.023	0.019
	Frontal horn	0.417	0.53	0.14	0.56	0.1	0.59	0.18	0.44
ADL	Temporal horn	0.019	0.36	0.018	0.61	0.026	0.71	0.021	0.27
	Body/occipital horn	0.004	0.032	0.0042	0.056	0.0025	0.053	0.0036	0.041
	Frontal horn	0.15	0.073	0.13	0.22	0.13	0.23	0.12	0.044
ADAScog Verbal Memory	Temporal horn	0.026	0.16	0.051	0.21	0.06	0.22	0.024	0.14
	Body/occipital	0.073	0.0015	0.081	0.002	0.071	0.002	0.07	0.0021
	horn
	Frontal horn	0.41	0.27	0.32	0.29	0.32	0.30	0.45	0.3
ADAScog Visuospatial	Temporal horn	0.19	0.67	0.23	0.61	0.21	0.57	0.18	0.69
	Body/occipital horn	0.005	0.019	0.0045	0.019	0.0053	0.018	0.0051	0.029
	Frontal horn	0.2	0.049	0.21	0.044	0.21	0.046	0.21	0.035
Maze errors	Temporal horn	0.036	0.23	0.038	0.47	0.037	0.33	0.035	0.24
	Body/occipital horn	0.61	0.18	0.6	0.21	0.6	0.21	0.6	0.18
	Frontal horn	0.51	0.047	0.43	0.02	0.49	0.032	0.47	0.037