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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Nature. 2012 Dec 12;493(7433):547–551. doi: 10.1038/nature11714

Figure 3. Allergic airway inflammation in Rac1-deficient mice is rescued by rIL-10.

Figure 3

a, Schematic of inducing airway inflammation and IL-10 treatment. b, H&E and PAS staining of lung sections from CCSP-Cre/Rac1fl/fl mice treated with or without rIL-10 (1 µg), representative of several experiments. c, BAL fluid analysis showing IL-4, IL-5 and IL-13 production by Rac1-deficient mice treated with or without rIL-10 (n = 8–10 mice per group, from three experiments). d, Image of mediastinal lymph nodes (n = 3 mice per group). e, Cytokine production by lymph node cells re-stimulated in vitro for 5 days with HDM (n = 5 mice per group). f, Airway resistance, compliance and pleural pressure in Rac1-deficient mice treated with or without rIL-10 (n = 5) (d–f, representative of three experiments). *P < 0.05, unpaired Student’s t-test with Welch’s correction (c, e, f).