Table II.
Extended Treatment NRT: Summary Results from Randomized Clinical Trials of at Least Six Months
| Study [citation #] | NRT | Extended Treatment (weeks) | Control Treatment (weeks) | Total N | Relative Risk | |
|---|---|---|---|---|---|---|
| Six Months | Longest Follow-Up | |||||
| Schnoll 2010 [64] | Patch | 24 wks. | 8 wks. | 568 | 1.6 | 1.0 (1year) |
| Tonnesen 1999 [65] | Patch | 26 wks.1
26 wks.2 |
12 wks.1
12 wks.2 |
14301
14312 |
0.91
1.22 |
1.01
1.22(1 year) |
| Hall [66] 2009 | Gum | 52 wks.3
52 wks.4 |
12 wks.3
12 wks.4 |
1993
2034 |
1.13
1.04 |
1.13
0.84 (2 years) |
| Joseph 2011 [67] | Patch, Gum, and/or Lozenge5 | 52 wks. | 8 wks. | 443 | 0.9 | 1.3 (18 months) |
1
Treatment based on 25mg patch; parent study included placebo group (not included here)
2
Treatment based on 15mg patch; parent study included placebo group (not included here)
3
Comparison during extended treatment period: gum vs. no gum
4
Comparison during extended treatment period: gum + counseling vs. counseling
5
Including combination NRT; outcomes not reported by single vs. combination NRT