. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: Drugs. 2013 Apr;73(5):407–426. doi: 10.1007/s40265-013-0038-y

Table III.

High Dose NRT: Summary Results from Randomized Clinical Trials of at Least Six Months

Study [citation #]	High Dose NRT	Control¹	Total N²	Minimum Smoking Level (cpd) of Sample³	Relative Risk
Study [citation #]	High Dose NRT	Control¹	Total N²	Minimum Smoking Level (cpd) of Sample³	Six Months⁴	Longest Follow-Up
Dale 1995 [72]	44mg patch	11mg patch, 22mg patch	53	10	1.3 (44 vs. 11) 1.4 (44 vs. 22)	21.6 (44 vs. 11) 1.9 (44 vs. 22) (1 year)
Jorenby 1995 [73]	44mg patch	22mg patch	504	15	0.9	6 months (see left)
Kalman 2006 [74]	42mg patch	21 mg patch	130	20	0.5	0.5 (9 months)
Hughes 1999 [75]	42mg patch 35mg patch	21mg patch	see below⁵	30	1.3 (42 vs. 21) 1.0 (35 vs. .21) 1.3 (42 vs. 35)	1.5 (42 vs. 21) 0.7(35 vs. 21) 2.1 (42 vs. 35) (1 year)
Tonnesen 1999 [65]	25mg patch⁶ 25mg patch⁷	15 mg patch⁶ 15mg patch⁷	1431⁶ 1430⁷	15	1.4⁶ 1.1⁷	1.4⁶ 1.1⁷ (1 year)
Killen 1999 [76]	25mg patch	15mg patch	408	26	1.1	1.0 (1 year)

Other (usually placebo) comparison groups may have been included; only standard course NRT comparison group(s) included here ² total sample size across groups of comparison (study may have included other groups, with larger N)

Based on eligibility criterion

⁴

most common follow-up point across all studies listed

⁵

Study was based on N=1039, with inclusion of 4^th group (placebo control). Sample size per group, across 3 groups included above, was unstated

⁶

Treatment provided for 12 weeks

⁷

Treatment provided for 26 weeks