Table 5.

Incremental cost effectiveness Ratios

	CE Ratio	ICER: cost per day of cocaine reduced	Adjusted ICER*	ICER: cost per gram of cocaine reduced	Adjusted ICER**
Study Conditions:
Std methadone maint. treatment	$\frac{\text{Costs}}{\text{Effect}}$	$\frac{\$1,015.34}{10.06}=\$101$	$34	$\frac{\$1,015.34}{1.05}=\$967$	$81
Disulfiram enhanced methadone maint. treatment	$\frac{\text{Additional}\text{cost}}{\text{Additional}\text{effectiveness}}$	$\frac{\$54.89}{4.63}=\$12$	$4	$\frac{\$54.89}{1.52}=\$36$	$3
Real World Conditions:
Std methadone maint. treatment	$\frac{\text{Costs}}{\text{Effects}}$	$\frac{\$732.07}{10.06}=\$73$	$24	$\frac{\$732.07}{1.05}=\$697$	$58
Disulfiram enhanced methadone maint. treatment	$\frac{\text{Additional}\text{cost}}{\text{Additional}\text{effectiveness}}$	$\frac{\$338.16}{4.63}=\$73$	$24	$\frac{\$338.16}{1.52}=\$222$	$19

^*Adjusted ICER uses the Adjusted Effectiveness for 12 weeks in the denominator. The Adjusted Effectiveness mutiplies by 3 the effectiveness in terms of days of cocaine used during the last 30 days, in order to obtain the effectiveness attributable to 3 months of treatment. This assumes that the reduction is stable over treatment and it is therefore possibly a lower bound of the ICER.

^**Adjusted ICER uses the Adjusted Effectiveness for 12 weeks in the denominator. The Adjusted Effectiveness multiplies by 12 the effectiveness obtained during the last week, to obtain the effectiveness attributable to 12 weeks of treatment. This assumes that the reduction is stable over treatment and it is therefore possibly a lower bound of the ICER.