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. 2012 May 31;22(4):836–852. doi: 10.1080/10543406.2010.528104

Table 5.

Comparison of design parameters and resulting expected sample sizes between (1) the first design in Table 1 in Whitehead et al. (2009), (2) the δ-minimax design with n1 constrained to be 45, and (3) the δ-minimax design with n1 unconstrained

Whitehead's δ-minimax n1 = 45 δ-minimax n1 unconstrained
n1 per arm 45 45 54
f 0 0.850 1.110
e1 2.730 2.367 2.303
n2 per arm 39 52 42
e2 1.977 2.023 2.018
Inline graphic(N | δ = 0) 128.75 109.75 118.45
Inline graphic(N | δ = 0.5) 152.71 139.73 140.38
Inline graphic(N | δ = 1) 146.79 142.28 140.71