Table 6.
Effects of GE on the expression of genes in adipose tissue.
Genes investigated | ND240 | HFD60 | HFD120 | HFD240 | HFDMET |
---|---|---|---|---|---|
Lipolysis | |||||
ATGL | 1.34 ± 0.34 | 1.78 ± 0.67a | 6.05 ± 0.42c | 5.69 ± 0.34c | 3.84 ± 0.98b |
HSL | 1.98 ± 0.07 | 2.99 ± 0.17a | 6.73 ± 0.42c | 6.54 ± 0.32c | 4.63 ± 1.16b |
| |||||
Differentiation | |||||
LPL | −1.05 ± 0.09 | −1.93 ± 0.18a | −1.12 ± 0.42b | −1.17 ± 0.47b | −2.22 ± 0.99a |
PPAR-γ | −1.69 ± 0.19 | −2.08 ± 0.69a | −1.69 ± 0.48ab | −1.02 ± 0.36c | −1.07 ± 0.16c |
SREBP-1c | −1.27 ± 0.65 | −1.01 ± 0.16c | −3.10 ± 0.44a | −2.25 ± 0.30ab | −2.30 ± 1.13ab |
Results are expressed as fold variation over the appropriate control groups; ND240 indicates fold increase over ND (normal diet control group), and HFD60, HFD120, HFD240, and HFDMET indicate fold increase over HFD (high-fat diet control group). Fold variations less than one were expressed as negative numbers (e.g., a fold variation of 0.50 is expressed as −2.00). Values expressed are means ± S.D of triplicate measurements. Statistical significance was calculated based on the mean ΔCT values by DMRT for only mice fed with high-fat diet with or without GE. For same gene with various treatment groups, superscripts in the different bar with different alphabets (a–c) were significantly different (P < 0.05). Superscripts with same alphabets were not significantly different between the treated groups (P > 0.05).