Table 1.

—Proposed Provisional Criteria for Lung-Dominant CTD

1. NSIP, UIP, LIP, OP, and DAD (or DIP if no smoking history), as     determined by surgical lung biopsy specimen or suggested     by high-resolution CT and
2. Insufficient extrathoracic features of a definite CTD to allow a     specific CTD designation and
3. No identifiable alternative etiology for IP and
4. Any one of the following autoantibodies or at least two of the     histopathology features:
Autoantibodies	Histopathology features
a. High-titer ANA (> 1:320) or    RF (> 60 IU/mL)	(a) Lymphoid aggregates with    germinal centers
b. Nucleolar-ANA	(b) Extensive pleuritis
c. Anti-CCP	(c) Prominent plasmacytic    infiltration
d. Anti-Scl-70	(d) Dense perivascular collagen
e. Anti-Ro
f. Anti-La
g. Anti-dsDNA
h. Anti-Smith
i. Anti-RNP
j. Anti-tRNA synthetase (eg,    Jo-1, PL-7, PL-12, and     others)
k. Anti-PM-Scl
l. Anticentromere

ANA = antinuclear antibody; CCP = cyclic citrullinated peptide; CTD = connective tissue disease; DAD = diffuse alveolar damage; DIP = desquamative interstitial pneumonia; IP = interstitial pneumonia; LIP = lymphocytic interstitial pneumonia; NSIP = nonspecific interstitial pneumonia; OP = organizing pneumonia; RF = rheumatoid factor; RNP = ribonucleoprotein; UIP = usual interstitial pneumonia.