Table 2.
Gray matter volumes, both globally and in cortical regions and select subcortical structures, for control (n=9) and LPS (n=9) progeny at one year of age.
| Neural Area | Control Mean (voxels) |
LPS Mean (voxels) |
p-value ICV uncorrected |
p-value ICV corrected |
|---|---|---|---|---|
| Intracranial volume | 88 512 ± 1 194 | 93 727 ± 2 625 | p ≤ .09 | N/A |
| Global GM | 50 648 ± 792 | 53 432 ± 895 | ||
|
| ||||
| Cortical Regions | ||||
| Prefrontal | 5 055 ± 127 | 5 501 ± 242 | ||
| Frontal | 5 436 ± 129 | 5 977 ± 191 | p ≤ .05 | p ≤ .05 |
| Cingulate | 1 628 ± 23 | 1 696 ± 63 | ||
| Temporal Auditory | 3 745 ± 78 | 3 911 ± 128 | ||
| Temporal Visual | 5 605 ± 99 | 5 863 ± 192 | ||
| Medial Temporal | 2 217 ± 43 | 2 286 ± 57 | ||
| Parietal | 5 812 ± 133 | 6 385 ± 234 | p ≤ .05 | p ≤ .07 |
| Occipital | 8 066 ± 156 | 8 211 ± 252 | p ≤ .06 | |
|
| ||||
| Sub-Cortical Regions | ||||
| Caudate | 606 ± 12 | 624 ± 16 | ||
| Putamen | 860 ± 11 | 921 ± 24 | p ≤ .05 | |
| Hippocampus | 400 ± 5 | 429 ± 11 | p ≤ .05 | |
| Amygdala | 381 ± 6 | 402 ± 11 | ||
| Cerebellum | 4 212 ± 98 | 4 536 ± 157 | ||
| Brainstem | 226 ± 8 | 230 ± 9 | ||
Mean±SEM is reported for raw GM volume estimates of monkeys from control and LPS pregnancies. The absolute value of each region of interest was divided by subject’s ICV to assess differential effects on GM of each region relative to global GM. The small size of the insula precluded accurate estimation and analysis. Blank spaces signify non-significant results.