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. Author manuscript; available in PMC: 2013 May 23.
Published in final edited form as: Trends Microbiol. 2011 Feb 25;19(6):263–267. doi: 10.1016/j.tim.2011.01.009

Figure 1.

Figure 1

Differential gene expression in C. albicans cells colonizing the gastrointestinal tract or causing oral thrush. (a) Colonization of the gastrointestinal (GI) tract without disease. Wild-type C. albicans cells established colonization of the murine GI tract as described previously [9]. RNA was extracted from colonizing C. albicans cells recovered from the murine cecum and expression of EFH1 was measured by real time quantitative reverse transcriptase PCR [12]. (b) Oral thrush in an immunosuppressed gnotobiotic newborn piglet. A germ-free piglet monocolonized in the GI tract with C. albicans and immunosuppressed developed oral thrush [8]; monocolonized piglets not treated with immunosuppressing drugs do not develop the extensive thrush shown here. (Image copyright © 2000, American Society for Microbiology. Reprinted with permission from [8]). RNA was extracted from pathogenic C. albicans cells recovered from the piglet tongue and EFH1 expression was analyzed as described above [12].