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. 2013 Apr 15;5(5):762–775. doi: 10.1002/emmm.201201891

Figure 3.

Figure 3

R-848 stimulates production of SPMs in murine allergic airway inflammation.

OVA sensitized and challenged mice treated with 200 µg R-848 or vehicle control (PBS) on Day 1 post-challenge were sacrificed at target time points and lungs analyzed.

A. LC-MS–MS chromatogram of Protectin D1 (PD1) identified in R-848-treated mouse lung.

B. Time-course of PD1 production during murine allergic airway inflammation. Black bars indicate baseline levels before administration of R-848. Blue bars indicate vehicle (PBS). Red bars indicate treatment with R-848. *p < 0.05; Xp < 0.05 compared to 0.