Table 6.
A review of effectiveness estimates for inactivated vaccines (ILI – influenza-like illness; ARI – acute respiratory infection; URTI – upper respiratory tract infection; LRTI – lower respiratory tract infection)
| Author (year of publication) | Study design | Type of vaccine | Control | Age of study population | Overall vaccine effectiveness | Lower confidence interval limit | Upper confidence interval limit |
|---|---|---|---|---|---|---|---|
| Colombo (2001) |
RCT |
Inactivated |
No intervention |
1-6 years |
0.77 |
0.45 |
1.31 |
| Cowling (2010) |
RCT |
Inactivated |
Placebo |
6-15 years |
ILI: 0.08
ARI: 0.01 |
0.04
0.01 |
0.16
0.02 |
| Gruber (1990) |
RCT |
Inactivated |
Placebo |
3-18 years |
0.85 |
0.41 |
1.74 |
| Principi (2003) |
RCT |
Inactivated |
No intervention |
0.5-5 years |
URTIs: 0.33
LRTI: 0.22
ILI: 0.26 |
0.19
0.08
0.18 |
0.57
0.34
0.36 |
| Rudenko (1993) |
RCT |
Inactivated |
Placebo |
7-14 years |
Year 1: 0.33
Year 2: 0.27 |
0.15
0.20 |
0.38
0.34 |
| Fujieda (2008) |
Cohort study |
Inactivated |
No intervention |
<6 years |
0.24 |
0.12 |
0.34 |
| Heikkinen (1991) |
Cohort study |
Inactivated |
No intervention |
1-3 years |
0.18 |
0.13 |
0.25 |
| Salleras (2006) | Cohort study | Inactivated | No intervention | 3-14 years | ILI: 0.75 | 0.61 | 0.84 |