Figure 11. Simulated glucose induced spikes behavior, [Ca²⁺]_c and IS changes at Na⁺ channel activation or blocking. (A) AP firing (V_p); (B) [Ca²⁺]_c (– – –) and relative IS (——). For simulation of Na⁺ channel activation the maximal conductance (g_mNa, Eq. A1, Appendix 2 in Supplemental Material) was initially increased to 20 nS, then g_mNa was decreased from 20 nS to 10 nS (basal level from Table S2) at arrow 1. For simulation of block of Na⁺ channels the g_mNa was decreased from 10 nS to 0.5 nS at arrow 2. Glucose induced APs were simulated as in Figure 3 up to persistent AP firing. Five second intervals are represented for every case.