Figure 13. Simulated glucose induced AP firing, [Ca²⁺]_c and relative IS at Na⁺ background current changes. (A) AP firing (V_p); (B) [Ca²⁺]_c (– – –) and relative IS (——). For simulation of Na⁺ background current activation the maximal conductance (g_bNa, Eq. A45, Appendix 2 in Supplemental Material) was initially increased up to 20 pS. Than g_bNa was decreased from 20 pS to 10 pS (basal level from Table S2) at arrow 1. For simulation of block of Na⁺ background current the g_bNa was decreased from 10 pS to 1 pS at arrow 2. Glucose induced persistent AP firing was simulated as in Figure 3. Five second intervals are represented for every case.