Figure 14. Simulated glucose induced AP spikes, [Ca²⁺]_c and IS changes after simulation of L-type Ca²⁺ channel blockers application. (A) AP firing (V_p); (B) [Ca²⁺]_c (– – –) and relative IS (——). The maximal conductance (g_mCaL, Eq. A6, Appendix 2 in Supplemental Material) was decreased from 2.7 nS (basal level from Table S2) to 0.2 nS at arrow. Glucose induced persistent AP firing was simulated as in Figure 3. Five second intervals are represented.