Figure 16. Simulated glucose induced spikes behavior, [Ca²⁺]_c and IS changes at T-type Ca²⁺ channel activation or blocking. (A) AP firing (V_p); (B) [Ca²⁺]_c (– – –) and relative IS (——). For simulation of T-type Ca²⁺ channel activation the maximal conductance (g_mCaT, Eq. A19, Appendix 2 in Supplemental Material) was initially increased up to 500 pS. Than g_mCaT was decreased from 500 pS to 250 pS (basal level from Table S2) at arrow 1. For simulation of block of T-type Ca²⁺ channel the g_mCaT was decreased from 200 pS to 50 nS at arrow 2. Glucose induced persistent AP firing was simulated as in Figure 3.