Figure 7. Modeling of glucose induced action potential firing, [Ca²⁺]_c and IS during a simulation of rapid delayed rectified voltage-gated K⁺ channels blocking. (A) AP firing (V_p); (B) [Ca²⁺]_c (– – –) and relative IS (——). For simulation of K_Dr channel blocking the maximal conductance (g_mKr, Eq. A24, Appendix 2 in Supplemental Material) was decreased from 18 nS (basal level) to 0 nS at arrow. Glucose induced AP firing was simulated up to persistent spike activity as in Figure 3. Five second intervals are represented.