Table 2.

SNPs show significant association with IBD and its subtypes CD and UC.

Chr	SNP	Base pair	All samples		Female samples		Male samples
			OR (95% CI)*	P value	OR (95% CI)	P value	OR (95% CI)	P value
IBD
16	rs2066845	49314041	2.34 (1.56–3.56)	4.87E-05	2.91 (1.65–5.12)	0.0002	1.80 (0.99–3.28)	0.054
22	rs6572	35951391	1.31 (1.15–1.49)	4.90E-05	1.30 (1.10–1.54)	0.0022	1.31 (1.07–1.60)	0.008
22	rs9607431	35959884	1.48 (1.22–1.79)	5.39E-05	1.37 (1.07–1.77)	0.013	1.63 (1.22–2.19)	0.001
22	rs2239773	35968235	0.76 (0.65–0.88)	0.00039	0.73 (0.60–0.90)	0.0028	0.79 (0.63–1.00)	0.049
22	rs2239774	35967599	1.35 (1.14–1.61)	0.00064	1.35 (1.07–1.70)	0.010	1.35 (1.04–1.76)	0.025
CD
16	rs2066845	49314041	3.51 (2.27–5.42)	1.48E-08	4.47 (2.46–8.12)	9E-07	2.63 (1.42–4.87)	0.002
2	rs10210302	233823578	0.72 (0.62–0.84)	1.82E-05	0.78 (0.64–0.96)	0.018	0.66 (0.53–0.82)	0.0002
22	rs9607431	35959884	1.59 (1.29–1.97)	2.00E-05	1.49 (1.12–2.00)	0.0067	1.72 (1.25–2.36)	0.0009
2	rs2241880	233848107	0.72 (0.62–0.84)	2.15E-05	0.78 (0.64–0.96)	0.018	0.66 (0.53–0.82)	0.0002
22	rs2239774	35967599	1.49 (1.22–1.81)	6.91E-05	1.49 (1.14–1.95)	0.0034	1.48 (1.11–1.97)	0.007
22	rs6572	35951391	1.34 (1.16–1.56)	0.00011	1.34 (1.09–1.64)	0.0053	1.36 (1.09–1.69)	0.007
16	rs2066844	49303427	1.73 (1.30–2.31)	0.00019	1.63 (1.11–2.40)	0.012	1.87 (1.20–2.90)	0.005
22	rs2239773	35968235	0.74 (0.61–0.88)	0.00083	0.69 (0.54–0.88)	0.0035	0.79 (0.61–1.03)	0.076
UC
22	rs746713	35589305	0.73 (0.61–0.86)	0.00030	0.72 (0.58–0.91)	0.0054	0.73 (0.56–0.95)	0.021

Notes: The table includes results of association analysis between genotypes and IBD as well as its subtypes CD and UC based on all samples, female samples only and male samples only, respectively. These SNPs are significant at Bonferroni corrected P-value 0.05 level (Unadjusted P-value at 8.6E-04) for the results based on all samples. In the association analysis, we also adjust gender.

Abbreviations: OR, odds ratio; CI, confidence interval.