Table 1. List of Some of the Impurities Identified in the pH 6.0 Extract of Methamphetamine Synthesized by the Leuckart Routea.
| no. | RT | impurity extracted at pH 6.0 | semiquantitative concentration mg/mL | intra-batch (n = 6) RSD | inter-batch (n = 20) RSD |
|---|---|---|---|---|---|
| 1 | 8.705 | 1-Phenyl-2-propanone | 5 × 10−3 | 6% | 37% |
| 2 | 8.872 | Amphetamine | 5 × 10−3 | 6% | 39% |
| 3 | 9.322 | 1-Phenyl-1,2-propanedione | 2 × 10−4 | 12% | 80% |
| 4 | 10.201 | N-N-Dimethylbenzylamine | 2 × 10−4 | 34% | 92% |
| 5 | 10.786 | Dimethylamphetamine (DMA) | 1 × 10−2 | 3% | 121% |
| 6 | 13.704 | N-Formylamphetamine | 2 × 10−4 | 12% | 72% |
| 7 | 14.613 | N-Formylmethamphetamine* | 5 × 10−4 | 16% | 147% |
| 8 | 15.052 | N-Acetylmethamphetamine* | 6 × 10−4 | 12% | 61% |
| 9 | 18.461 | Unidentified | 7 × 10−4 | 17% | 69% |
| 10 | 18.619 | α,α-Dimethyldiphenethylamine* | 4 × 10−4 | 15% | 59% |
| 11 | 18.661 | α,α-Dimethyldiphenethylamine* | 5 × 10−4 | 15% | 75% |
| 12 | 21.253 | Pyridine 7 and 14* | 2 × 10−5 | 38% | 73% |
| 13 | 23.261 | N-Methyl-N-(1-methyl-2-phenylethyl)-2-phenylacetamide* | 5 × 10−3 | 19% | 63% |
a
RSDs were calculated using peak areas normalized to the sum of the CHAMP target impurities present in the relevant chromatogram. Route specific impurities for the Leuckart route are emboldened, and CHAMP target impurities are marked with an asterisk.