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Proposed mechanism of multistage delivery of micellar nanotherapeutics to tumors. Following navigation in blood vessels, multistage vectors (MSVs) marginate in tumor vasculature, accumulating in smaller capillaries. MSVs then become intravascular drug-delivery depots, releasing paclitaxel-containing polymer micelles in a sustained fashion over time. Reproduced with permission from Blanco et al., Cancer Letters, 2012 [108]
