Table 4.
Stage 1 and 2 validation of brief FHQ using pooled data
| Condition | Question number(s) | Sensitivity, % (95% CI) [n] | Specificity, % (95% CI) [n] | Positive likelihood ratio | Negative likelihood ratio | Positive predictive value, % | False-positive rate, % |
|---|---|---|---|---|---|---|---|
| Diabetes | 3 | 98 (95 to 99%) [208/213] |
94 (92 to 95) [854/913] |
15.11a | 0.03a | 77.9 | 0.6 |
| Ischaemic heart disease | 2 | 93 (87 to 96) [141/152] |
81 (79 to 84) [804/990] |
4.94b | 0.09a | 43.1 | 1.3 |
| Breast cancer | 6 or 8 | 81 (67 to 91) [39/48] |
83 (80 to 85) [598/723] |
4.70 | 0.22 | 23.8 | 1.5 |
| Colorectal cancer | 10 or 11 | 96 (80 to 99) [24/25] |
88 (86 to 89) [976/1114] |
7.75b | 0.05a | 14.9 | 0.1 |
a
Strong clinical significance.
b
Modest clinical significance.