Table 1.
Half maximal inhibitory concentration values of a mutant heat shock protein cage (HspG41C) carrying doxorubicin and free doxorubicin
| Cells | Exposure time (hours) | IC50 (μM) | |
|---|---|---|---|
|
| |||
| HspG41C–DOX | Free DOX | ||
| Huh-7 (hepatoma) | 24 | 16 | >30 |
| 48 | 5.5 | 10 | |
| 72 | 1.1 | 1.9 | |
| HepG2 (hepatoma) | 24 | 20 | 4.5 |
| 48 | 7.8 | 1.2 | |
| 72 | 4.8 | 1.2 | |
| Suit-2 (pancreatic cancer) | 24 | >30 | >30 |
| 48 | 4.5 | 1.6 | |
| 72 | 2.7 | 1.4 | |
Abbreviations: DOX, doxorubicin; HspG41C–DOX, mutant heat shock protein cage (HspG41C) carrying doxorubicin; IC50, half maximal inhibitory concentration.