Table 1.
Characteristics of study population, stratified by ethnicity and case–control status, The Breast Cancer Health Disparities Study (n = 7,733)
| Non-Hispanic Whites (n = 3,030)
|
p Valuea | Hispanics (n = 4,703)
|
p Valuea | p Valueb | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases
|
Controls
|
Cases
|
Controls
|
||||||||
| No. | % | No. | % | No. | % | No. | % | ||||
| Total subjects | 1,431 | 1,599 | 2,093 | 2,610 | |||||||
| Study site | |||||||||||
| 4-CBCS | 1,177 | 82.3 | 1,335 | 83.5 | 0.37 | 579 | 27.7 | 736 | 28.2 | 0.94 | <0.001 |
| Mexico | – | – | 816 | 39.0 | 994 | 38.1 | |||||
| SFBCS | 254 | 17.8 | 264 | 16.5 | 698 | 33.4 | 880 | 33.7 | |||
| Menopausal status | |||||||||||
| Pre-menopausal | 475 | 34.1 | 494 | 31.5 | 0.13 | 831 | 41.2 | 1,027 | 40.7 | 0.71 | <0.001 |
| Post-menopausal | 919 | 66.9 | 1,075 | 68.5 | 1,186 | 58.8 | 1,499 | 59.3 | |||
| Body mass index (kg/m2)c | |||||||||||
| <25 | 651 | 46.1 | 699 | 44.4 | 0.30 | 482 | 23.4 | 453 | 17.6 | <0.001 | <0.001 |
| 25–29.9 | 411 | 29.1 | 465 | 29.5 | 762 | 37.0 | 951 | 36.9 | |||
| 30+ | 350 | 24.8 | 412 | 26.1 | 818 | 39.7 | 1,172 | 45.5 | |||
| History of type 2 diabetes | |||||||||||
| Yes | 91 | 7.2 | 122 | 8.6 | 0.20 | 308 | 16.6 | 386 | 16.6 | 0.98 | <0.001 |
| No | 1,166 | 92.8 | 1,299 | 91.4 | 1,548 | 83.4 | 1,945 | 83.4 | |||
| 1st degree family history of breast cancer | |||||||||||
| No | 1071 | 77.4 | 1,289 | 84.5 | <0.001 | 1,799 | 88.1 | 2,326 | 91.8 | <0.001 | <0.001 |
| Yes | 312 | 22.6 | 237 | 15.5 | 244 | 11.9 | 208 | 8.2 | |||
| Estrogen/progesterone receptor (ER/PR) status | |||||||||||
| ER+/PR+ | 670 | 68.4 | – | – | 595 | 62.1 | – | – | 0.002 | ||
| ER+/PR− | 115 | 11.8 | – | 114 | 11.9 | – | |||||
| ER−/PR+ | 15 | 1.5 | – | 27 | 2.8 | ||||||
| ER−/PR− | 179 | 18.3 | – | 222 | 23.2 | ||||||
| Percentage of Native American genetic admixture | |||||||||||
| ≤0.28 | 1,420 | 99.2 | 1,591 | 99.5 | 0.21 | 276 | 13.2 | 280 | 10.7 | 0.001 | <0.001 |
| 0.28–0.70 | 7 | 0.5 | 7 | 0.4 | 1,373 | 65.6 | 1,697 | 65.0 | |||
| >0.70 | 4 | 0.3 | 1 | 0.1 | 444 | 21.2 | 633 | 24.3 | |||
| History of menopausal hormone use | |||||||||||
| Yes | 795 | 69.2 | 899 | 69.2 | 0.98 | 616 | 32.5 | 713 | 29.5 | 0.03 | <0.001 |
| No | 354 | 30.8 | 401 | 30.8 | 1280 | 67.5 | 1,704 | 70.5 | |||
| Education level | |||||||||||
| Less than high school | 71 | 5.0 | 79 | 5.0 | 0.57 | 1088 | 52.8 | 1,538 | 60.2 | <0.001 | <0.001 |
| High school grad/GED | 284 | 20.1 | 338 | 21.4 | 377 | 18.3 | 419 | 16.4 | |||
| College education | 1,059 | 74.9 | 1168 | 73.6 | 594 | 29.0 | 597 | 23.4 | |||
| Parity | |||||||||||
| Nulliparous | 249 | 17.6 | 248 | 15.7 | 0.001 | 225 | 10.8 | 181 | 7.0 | <0.001 | <0.001 |
| 1–2 | 622 | 44.0 | 638 | 40.3 | 774 | 37.2 | 790 | 30.5 | |||
| 3–4 | 441 | 31.2 | 529 | 33.4 | 729 | 35.0 | 997 | 38.4 | |||
| 5+ | 102 | 7.2 | 167 | 10.6 | 353 | 17.0 | 626 | 24.1 | |||
| Mean | (SD) | Mean | (SD) | p Valued | Mean | (SD) | Mean | (SD) | p Valued | p Valuee | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 55.9 | 11.2 | 56.7 | 12.3 | 0.05 | 52.7 | 10.6 | 52.3 | 10.8 | 0.25 | <0.001 |
Missing information: education, n = 121; parity, n = 62; menopausal status, n = 227; menopausal hormone use, n = 971; family history of breast cancer, n = 247; history of diabetes, n = 868; body mass index, n = 107; estrogen receptor status, n = 5797 (cases only)
Case–control comparison within ethnicity. p Values from Chi-square tests
Ethnic group comparison, regardless of case–control status. Mantel–Haenszel Chi-square p values from Chi-square tests
Body mass index (BMI) in referent year calculated as kilograms (kg)/meters (m)2
Case–control comparison within ethnicity. p Values from t tests
Ethnic group comparison, regardless of case–control status. p Values from t tests